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Guanidine HCl is a chaotropic agent used to disrupt the structure of proteins. As a denaturant it acts to unfold proteins and turn them into their original polypeptide chains. It is commonly utilized in the isolation of RNA by dissociating the RNA into its nucleic acids and protein forms. At higher concentrations Guanidine HCl decreases enzyme activity. It is also used to increase the solubility of hydrophobic molecules.
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NH2C(NH)NH2 · HCl ^ F.W. 95.53 g/mol ^ CAS# 50-01-1 |
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Test |
Specifications |
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Bio Ultra |
Bio Synthesized |
Bio Industrial |
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GHL-13 |
GHL-12 |
GHL-11 |
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Manufactured in the |
Pass |
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Appearance and Color |
White/Crystals |
White/Crystals |
White/Crystals |
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Assay, dried basis |
99.9% min. |
99.5% min. |
99.0% min. |
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Identification (IR) |
Match Reference |
Match Reference |
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Ethyl Alcohol Solubility (5%) |
Clear/Colorless |
Clear/Colorless |
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Solubility (H2O, 6M) |
Clear/Colorless |
Clear/Colorless |
Clear/Colorless |
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Water Insolubles |
0.15% max. |
0.3% max. |
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pH |
4.5-6.0 |
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Residue on Ignition |
0.05% max. |
0.05% max. |
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LOD |
0.3% max. |
0.5% max. |
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Free Acid |
0.01% max. |
0.01% max. |
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Sulfate |
0.005% max. |
0.005% max. |
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Nitrate |
Pass |
Pass |
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Free CN |
0.00001% max. |
0.00001% max. |
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0.01 max. @ 280 |
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0.03 max. @ 275 |
0.03 max. @ 275 |
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Absorbance |
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0.03 max. @ 260 |
0.03 max. @ 260 |
0.03 max. @ 260 |
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0.15 max. @ 230 |
0.2 max. @ 230 |
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0.2 max. @ 225 |
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Sodium (Na) |
0.005% max. |
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Potassium (K) |
0.005% max. |
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Arsenic (As) |
0.00005% max. |
0.00005% max. |
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Calcium (Ca) |
0.0001% max. |
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Copper (Cu) |
0.00002% max. |
0.00002% max. |
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Iron (Fe) |
0.0001% max. |
0.0002% max. |
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Magnesium (Mg) |
0.0001% max. |
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Lead (Pb) |
0.00005% max. |
0.00005% max. |
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Zinc (Zn) |
0.0001% max. |
0.0001% max. |
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Melt Range/C |
184-187 |
184-187 |
184-188 |
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RNase |
None Detected |
None Detected |
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DNase |
None Detected |
None Detected |
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Protease |
None Detected |
None Detected |
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Guanidine Hydrochloride Inhibits Mammalian Orthoreoviris Growth by Reversibly Blocking the Synthesis of Double-Stranded RNA
EnvironmentalChemistry.com chemical Database
Unfolding and Inactivation of Abalone (Haliotis diversicolor) Alkaline Phosphatase During Denaturation by guanidine Hydrochloride
Drug Card for Guanidine
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| Bio Industrial (Good) Quality tested from approved suppliers of BBS for Industry-Standard use. |
| Bio Synthesized (Better) Manufactured in a quality system based facility offering traceability and consistent supply. |
| Bio Ultra (Best) Manufactured at BBS to meet the highest quality and regulatory standards. |
